Controlled processing and transfer
Define CO₂ processing and pulse-transfer conditions around your study so you can investigate how the process affects your formulation.
CO₂ formulation research platform
Make the next experiment more deliberate.
The ME-2.5 gives formulation teams a configurable platform to develop and compare active–carrier processing methods using controlled CO₂ transfer.
For pharmaceutical teams, evaluate poorly soluble API-carrier questions through controlled, formulation-specific studies.
Request a 15-minute technical discussion with our team.
Designed for research. Application outcomes are formulation-specific and must be evaluated.
2.5 Lprocessing vessel
Controlled CO₂antisolvent pulse transfer
Static mixertransfer path
10 Lcollection vessel
The ME-2.5 platform
Controlled CO₂ processing for active–carrier research.
The ME-2.5 Molecular Encapsulator combines a 2.5 L processing vessel, controlled CO₂ antisolvent pulse transfer through a static-mixer path, and a separate 10 L collection vessel.
Develop and compare formulation methods, investigate processing variables, and collect evidence that helps your team select its next experiment.
Features and what they help you do
Separate processing and collection
Follow a defined path from the 2.5 L vessel through the static mixer to the 10 L collector, then characterize the recovered material.
Options for your formulation
Discuss conventional stirring and compatible cosolvents to support preparation and active–carrier contact. Confirm each option in your configuration.
A capability for recurring studies
Build application knowledge across repeated projects and compare CO₂ processing with relevant methods using matched study conditions.
Applications to evaluate
Pharmaceutical and CDMO formulation
Investigate poorly soluble active–carrier systems and compare formulation behavior using appropriate analytical methods.
Excipient and cyclodextrin development
Explore active–carrier combinations and generate application-specific evidence for formulation decisions.
Ingredient and nutraceutical development
Study incorporation into water-based products, dispersion, active loading, and recovery for a defined ingredient formulation.
Academic and shared-laboratory research
Support funded studies in formulation and high-pressure processing where multiple projects justify a shared platform.
Application fit and performance depend on the formulation, configuration, and study conditions. Discuss your active, carrier, and target outcome with our team.
For your team
Different roles. A shared formulation question.
From designing an experiment to planning a shared laboratory, each team member brings a different question to the ME-2.5 evaluation.
For pharmaceutical formulation scientists
Investigate poorly soluble API-carrier systems through controlled comparisons. Define the question around dissolution, precipitation, loading, or stability, then characterize the recovered material against relevant controls.
Your focus: Interpretable evidence, appropriate analytical methods, and results your colleagues can reproduce.
For CDMO formulation and R&D leaders
Evaluate whether a reusable CO₂ research capability fits your client-program pipeline. Compare ownership with existing equipment and outsourced development, considering project demand, staffing, analytical support, and complete installed cost.
Your focus: Useful capability across multiple programs, realistic utilization, and a defensible capital decision.
For ingredient and excipient developers
Explore carrier and process combinations for a defined ingredient application. Assess incorporation into water-based products, active loading, recovery, and handling to develop meaningful samples and reusable application knowledge.
Your focus: Application evidence that supports credible customer discussions and formulation decisions.
For academic researchers and educators
Build a research program around controlled CO₂ processing, formulation variables, and repeat studies. Evaluate shared use across investigators and researcher training alongside instrument access, service, and an ongoing operating plan.
Your focus: Reproducible studies, researcher development, and a sustainable shared-laboratory capability.
For process engineers and lab operations teams
Scope the practical requirements before installation. Review configuration, utilities, site responsibilities, cleaning and containment, operating limits, acceptance criteria, documentation, training, spares, and support with the technical team.
Your focus: Clear implementation responsibilities, maintainability, and an equipment proposal that matches your site.
Bring your scientific, budget, and operations stakeholders into the same discussion. Formulation outcomes must be established experimentally; configuration and support scope should be confirmed for your project.
Request a technical discussionThe base process path
A defined path from processing vessel to collection.
The supplied base configuration combines a 2.5 L processing vessel, controlled CO₂ antisolvent pulse transfer, a static-mixer transfer path, and a separate 10 L collector.
Prepare the formulation
Define the active, carrier, and preparation method for the question being studied.
Condition with CO₂
Use controlled processing conditions as experimental variables in the study plan.
Transfer through the mixer
Move the processed material through the static-mixer transfer path in a controlled pulse.
Collect and characterize
Recover the material and use fit-for-purpose analytical methods to assess the result.
2.5 L vesselProcessing
CO₂ pulse transferControlled path
10 L vesselCollection
Schematic of the described base configuration; final operating conditions and supplied-equipment specification should be confirmed for each proposal.
Configuration choices
Start with the base. Scope the options around your study.
Some preparation and feed approaches are selectable options or proposed research configurations. They need a technical review before they are represented as included equipment.
Base configuration described
Processing and collection path
2.5 L processing vessel, controlled CO₂ antisolvent pulse transfer through a static-mixer path, and separate 10 L collection vessel.
Selectable options to review
Mixing and compatible cosolvents
Conventional stirring and compatible cosolvents can be discussed as options. Their value depends on the active, carrier, preparation, and target experiment.
Proposed research configurations
External preparation and pumped feeds
External preparation or multi-feed arrangements may be considered for research. Availability, design, and scope must be confirmed for the intended configuration.
Application-dependent
Process conditions and recovery
Pressure, temperature, CO₂ delivery, feed preparation, transfer, and recovery conditions should be defined with the study and verified against the approved equipment specification.
A configuration conversation should identify the base unit, options, site requirements, training, service, acceptance documentation, and application-development scope before a purchase decision.
Technical evaluation
Build confidence in the experiment and the implementation.
A useful evaluation connects an active–carrier question to a study plan, analytical method, operating envelope, and installation scope. Bring your technical and operations stakeholders into the conversation early.
Request a technical discussionApplication fit
Is equipment ownership the right next step?
ME-2.5 is most relevant when your team has recurring research needs, access to analytical methods, and a practical plan to operate the system.
You have a named active–carrier or formulation question to investigate.
You can access appropriate samples and fit-for-purpose analytical support.
There is a recurring project pipeline or shared-use case for the capability.
A trained operator, site review, and internal project sponsor are available.
If the application is uncertain or the demand is occasional, begin by defining a feasibility study or another evaluation path before assuming equipment ownership is the best fit.
Research and technical questions
Frequently asked questions.
Explore the formulation questions a study can address and the details to discuss before configuring your platform.
Can ME-2.5 help us investigate solubility and dissolution?
The platform supports studies comparing active–carrier processing methods. Measure solubility and dissolution in the intended medium under defined test conditions, and compare the processed formulation with relevant controls. Improvement must be demonstrated for your formulation.
How will our formulation disperse or precipitate after dilution?
Evaluate the recovered material after preparation, dilution, and exposure to its target environment. A study can compare dispersion and precipitation behavior across processing conditions; the outcome depends on the formulation.
How much active is retained in the recovered material?
Use an appropriate assay and a material balance to measure loading and active retention. Compare recovered material across repeat runs to assess consistency.
Will the formulation remain stable during storage and handling?
Establish physical and chemical stability with a defined storage and handling protocol. Processing results alone do not establish stability or shelf life.
Can we reproduce the process and recover material consistently?
Define the process settings, sampling plan, recovery procedure, and repeat runs before the study. Compare analytical results and material recovery to assess repeatability.
Does ME-2.5 guarantee better solubility or bioavailability?
No. Those are application outcomes to establish through formulation-specific testing. The platform supports research and comparison; it does not establish that every formulation improves or that CO₂ always outperforms another method.
What is included in the base configuration?
The supplied description identifies a 2.5 L processing vessel, controlled CO₂ antisolvent pulse transfer, a static-mixer transfer path, and a separate 10 L collection vessel. Confirm the approved equipment specification and proposal for final inclusions.
Are stirring, cosolvents, and additional feeds standard?
Conventional stirring and compatible cosolvents are described as options. External preparation and multi-feed arrangements are proposed research configurations. Ask the team to confirm availability, engineering scope, and what is included for your project.
What should our team prepare before a technical call?
Bring the active and carrier, the formulation problem, current method and evidence, target analytical endpoints, sample constraints, expected project frequency, site and utility questions, and the people who will operate or approve the equipment.
Request a 15-minute technical discussion
Discuss your API-carrier question with our team.
Share your formulation question, study goals, or configuration details. Submit the form to request a 15-minute technical discussion. Our team will be in touch to coordinate a time.
Prefer to call? 612-790-3846.