Screening Study
Investigate one primary formulation question through agreed ME lab runs. Receive a decision report with methods, results including negative findings, limitations, and a recommended next step.
CO₂ molecular encapsulation · ME-2.5 / ME-1.25
Your formulation question.
A measurable next step.
Can CO₂-assisted processing help your active meet its dissolution, loading, stability, or release target? Start with a scoped ME Feasibility Study, or build the capability in-house with ME-2.5 or ME-1.25.
For pharmaceutical formulation teams, agricultural formulators, and industrial materials developers. Define your active and carrier and the result you need.
Paid studies are scoped and quoted per project. No equipment purchase obligation.
Prefer in-house research? Explore the equipment.
2.5 Lprocessing vessel
Controlled CO₂antisolvent pulse transfer
Static mixertransfer path
10 Lcollection vessel
ME Feasibility Study
Test the application before committing to equipment.
Start with one active–carrier question and a written scope. Agree the baseline, acceptance criteria, sample needs, analytical responsibilities, and schedule before lab work begins.
Comparison Study
A separately scoped study with a baseline comparison design, application-specific endpoints, a mid-study check-in, and a results readout. Select the measurements that matter to your next decision.
Define the test: name your active and carrier and the result you need.
Plan the materials: confirm sample quantity, SDS, shipping instructions, and who performs each assay.
Read the evidence: review methods, data, limits, and whether criteria were met, unmet, or inconclusive.
Choose the next step: stop, optimize, pilot, or discuss equipment. Further work is separately scoped.
A study stands alone and does not obligate you to buy ME-1.25 or ME-2.5. Prices and schedules depend on the agreed project. A negative or inconclusive scientific result can still be a completed study.
The ME-2.5 platform
Controlled CO₂ processing for active–carrier research.
The ME-2.5 Molecular Encapsulator combines a 2.5 L processing vessel, controlled CO₂ antisolvent pulse transfer through a static-mixer path, and a separate 10 L collection vessel.
Develop and compare formulation methods, investigate processing variables, and collect evidence that helps your team select its next experiment.
Where dry feed may help: For suitable recipes using no added liquid organic process solvent, CO₂ separation on depressurization may avoid a bulk liquid-solvent evaporation or stripping step. Co-solvent is an option we scope for your study. Wet-feed routes need their own removal and residual assessment. Confirm moisture and residuals analytically.
Features and what they help you do
Controlled processing and transfer
Define CO₂ processing and pulse-transfer conditions around your study so you can investigate how the process affects your formulation.
Separate processing and collection
Follow a defined path from the 2.5 L vessel through the static mixer to the 10 L collector, then characterize the recovered material.
Options for your formulation
Co-solvent is an option we scope for your study.
A capability for recurring studies
Build application knowledge across repeated projects and compare CO₂ processing with relevant methods using matched study conditions.
Applications to evaluate
Pharmaceutical formulation
Compare a selected API–carrier route against your current method. Define dissolution, true solubility, loading, morphology, moisture, residuals, or stability endpoints as appropriate. Review cyclodextrin, polymer, or lipid concepts for technical fit before selecting a configuration.
Agricultural formulations
Evaluate a selected crop-protection active or fertilizer additive against release, retained activity, storage, and handling targets. Include redispersion, sprayability, coating workflow, and cost per application in the comparison.
Industrial materials and coatings
Define the particle, slurry, substrate, or finished-product matrix. Compare deposition, adhesion, dispersibility, release trigger, and compatibility with the existing process, alongside total processing cost.
Ingredient, food, and academic research
Scope a specific question around oil-to-powder conversion, aroma retention, active loading, or release. Agree sample quantities, analytical methods, thermal conditions, and the intended product matrix before evaluating results.
These are applications to evaluate, not validated performance claims. Carrier compatibility, processing mode, and configuration must be established for the selected material. Ingredient development and equipment ownership are different purchase paths.
ME-1.25 Molecular Encapsulator
Another vessel size for your research program.
Evaluate the ME-1.25 for CO₂-assisted formulation research with a 1.25 L process vessel and a separate 5 L collector. Choose the model around your experimental needs, analytical plan, and operating requirements.
Controls for a defined study
The base equipment includes a main CO₂ pump, static mixer, vessel heating, heat exchange, inline preheating, automated valves, and recipe operation through HMI and PLC controls.
- Capacity: 1.25 L process vessel and 5 L collector.
- Operating envelope: 276 bar (4,000 psi) standard. Higher pressure available on a special quote. Inlet preheater and mixing vessel rated to a maximum of 100 °C.
- Temperature control: Independently controlled inlet, mixing-vessel, and collection temperatures.
- Electrical supply: Single phase, 208–240 V, 50 or 60 Hz.
- Standard documentation: Operating and installation instructions, utility requirements, and standard manufacturing checks.
Scope options around the application
Separate selections include closed-loop process pressure control, a process chiller, injection pumps, and additional CO₂ supply equipment. Co-solvent is an option we scope for your study. Higher-pressure configurations and qualification services are scoped separately.
Discuss particle-formation or inclusion-complex research against the proposed setup. Process-specific feed or nozzle arrangements and formulation outcomes must be confirmed for your study.
Discuss ME-1.25 with our teamCompare the vessel capacities
| Configuration | ME-1.25 | ME-2.5 |
|---|---|---|
| Process vessel | 1.25 L | 2.5 L |
| Collection vessel | 5 L | 10 L |
| Configuration review | Confirm operating envelope, accessories, and site scope | Confirm base equipment, preparation options, and site scope |
Vessel volume is a configuration difference, not a guarantee of throughput or equivalent formulation performance. Establish model fit through your intended study and approved equipment specification.
For your team
Different roles. A shared formulation question.
From designing an experiment to planning a shared laboratory, each team member brings a different question to the ME-2.5 or ME-1.25 evaluation.
For pharmaceutical formulation scientists
Start with the API and carrier chemistry, intended route, and current formulation limit. Choose assays that distinguish true solubility from fine dispersion, and assess dissolution, loading, morphology, or stability against relevant controls.
Your focus: Evidence for your specific active and route, with methods and limits your colleagues can assess.
For process R&D and capital decision-makers
Connect the formulation result to a reproducible process record, downstream operations, and total cost. Consider equipment ownership when recurring programs, analytical access, staffing, and site readiness justify it.
Your focus: A defensible decision to stop, do more work, or invest in in-house capability.
For agricultural formulators
Define the required initial effect, release profile, retained activity, and practical handling. Compare a dry format with the current liquid or solid product, including any extra mixing, redispersion, coating, or application steps.
Your focus: Useful performance at an acceptable loading and cost per application.
For industrial and ingredient developers
Specify the finished-product matrix, carrier, release trigger, and process constraints. Separate a need for ready-to-use ingredients from a development study or equipment purchase.
Your focus: Measurable sample performance, compatibility, and delivered cost.
For academic researchers and collaborators
Plan the smallest useful experiment around your research question, available samples, analytical responsibilities, and funding timeline. Start with nonconfidential information and request a technical packet for internal review.
Your focus: An interpretable study, an achievable budget, and a clear next research decision.
Begin with a nonconfidential overview of your application. We can discuss a relevant technical packet before detailed scoping. If a candidate or funding is still pending, use the discussion to identify what information you need next.
Request a technical discussionME-2.5 base process path
A defined path from processing vessel to collection.
The supplied base configuration combines a 2.5 L processing vessel, controlled CO₂ antisolvent pulse transfer, a static-mixer transfer path, and a separate 10 L collector.
Prepare the formulation
Define the active, carrier, and preparation method for the question being studied.
Condition with CO₂
Use controlled processing conditions as experimental variables in the study plan.
Transfer through the mixer
Move the processed material through the static-mixer transfer path in a controlled pulse.
Collect and characterize
Measure the agreed endpoints against your current formulation: loading, recovery, dissolution, release, or other application-specific criteria. Include downstream handling in the assessment.
2.5 L vesselProcessing
CO₂ pulse transferControlled path
10 L vesselCollection
Schematic of the described base configuration; final operating conditions and supplied-equipment specification should be confirmed for each proposal.
ME-2.5 configuration choices
Start with the base. Scope the options around your study.
Some preparation and feed approaches are selectable options or proposed research configurations. They need a technical review before they are represented as included equipment.
Base configuration described
Processing and collection path
2.5 L processing vessel, controlled CO₂ antisolvent pulse transfer through a static-mixer path, and separate 10 L collection vessel.
ME-2.5 pressure: 276 bar (4,000 psi) standard. Higher pressure available on a special quote.
Selectable options to review
Study options
Co-solvent is an option we scope for your study.
Proposed research configurations
External preparation and pumped feeds
External preparation or multi-feed arrangements may be considered for research. Availability, design, and scope must be confirmed for the intended configuration.
Application-dependent
Process conditions and recovery
Pressure, temperature, CO₂ delivery, feed preparation, transfer, and recovery conditions should be defined with the study and verified against the approved equipment specification.
A configuration conversation should identify the base unit, options, site requirements, training, service, acceptance documentation, and application-development scope before a purchase decision.
Technical evaluation
Compare with the process you already use.
A useful study connects formulation performance to the whole workflow. Consider feed preparation, recovery, redispersion or coating, analytical requirements, material quantity, and total cost. Define what improvement would justify the change.
Request a technical discussionApplication fit
Is equipment ownership the right next step?
Ownership is most relevant when recurring projects justify an in-house platform. For an uncertain application or occasional demand, use a scoped study to inform the next decision.
You have a named active–carrier or formulation question to investigate.
You can access appropriate samples and fit-for-purpose analytical support.
There is a recurring project pipeline or shared-use case for the capability.
A trained operator, site review, and internal project sponsor are available.
Buying a finished ingredient, commissioning a feasibility study, and purchasing equipment are different commitments. Tell us which decision you are making so the discussion matches your needs.
Research and technical questions
Frequently asked questions.
Explore the formulation questions a study can address and the details to discuss before configuring your platform.
Is this formulation equipment or botanical extraction equipment?
ME-1.25 and ME-2.5 are presented here as CO₂-assisted molecular encapsulation and particle-engineering research platforms for active–carrier formulations. Start with the material and formulation endpoint so we can assess the processing route and required configuration.
Is every ME process dry or free of organic solvents?
No. For a suitable dry-feed recipe without added liquid organic process solvent, CO₂ separation on depressurization may avoid bulk liquid-solvent evaporation or stripping. Wet feeds are a separate option. Co-solvent is an option we scope for your study. Moisture and residuals must be measured for the chosen process.
How do we distinguish solubility, dispersion, and inclusion?
Use analytical methods that answer the actual question. A finer dispersion does not establish true aqueous solubility, and a recovered powder does not establish cyclodextrin inclusion. Define the medium, controls, separation and assay method, and any inclusion-characterization work in the study scope.
Can we evaluate polymers, lipids, or biological materials?
Raise the specific carrier and material during technical review. Polymer and lipid processing, route suitability, feed arrangements, and recovery need application-specific confirmation. Whole microbes are not guests for cyclodextrin inclusion cavities; any carrier or drying study must separately assess viability, handling, and intended use.
Can a study establish controlled release or shelf life?
Only application-specific testing can establish those outcomes. Define the release trigger, target profile, finished-product matrix, storage conditions, and test duration. Agricultural work should include initial effect, residual performance, customer handling, and cost per application where relevant.
What do we receive from an ME Feasibility Study?
Each study has a written scope, agreed acceptance criteria, sample and SDS instructions, planned lab runs, and a decision report covering methods, results including negatives, limits, and recommended next steps. A Comparison Study adds a separately agreed baseline comparison and application-specific measurements. Confirm the scope, responsibilities, quote, and schedule before starting.
Does a study require us to buy equipment?
No. The study stands alone. Further optimization, pilot work, and equipment are separate decisions and separately scoped. A negative or inconclusive scientific result can still complete the agreed study.
What if we do not have an active project yet?
Request nonconfidential platform information or a technical packet for internal review. A study is most useful once you can name a candidate material, the current limitation, and the result you need to measure. Equipment ownership also needs a realistic recurring-use case.
How does ME-1.25 differ from ME-2.5?
ME-1.25 uses a 1.25 L process vessel and a 5 L collector; the described ME-2.5 configuration uses a 2.5 L process vessel and a 10 L collector. Compare the intended study, operating envelope, selected options, analytical requirements, and installation scope with our team. Larger vessel volume does not establish higher throughput or equivalent formulation outcomes.
Can ME-2.5 help us investigate solubility and dissolution?
The platform supports studies comparing active–carrier processing methods. Measure solubility and dissolution in the intended medium under defined test conditions, and compare the processed formulation with relevant controls. Improvement must be demonstrated for your formulation.
How will our formulation disperse or precipitate after dilution?
Evaluate the recovered material after preparation, dilution, and exposure to its target environment. A study can compare dispersion and precipitation behavior across processing conditions; the outcome depends on the formulation.
How much active is retained in the recovered material?
Use an appropriate assay and a material balance to measure loading and active retention. Compare recovered material across repeat runs to assess consistency.
Will the formulation remain stable during storage and handling?
Establish physical and chemical stability with a defined storage and handling protocol. Processing results alone do not establish stability or shelf life.
Can we reproduce the process and recover material consistently?
Define the process settings, sampling plan, recovery procedure, and repeat runs before the study. Compare analytical results and material recovery to assess repeatability.
Does ME-2.5 guarantee better solubility or bioavailability?
No. Those are application outcomes to establish through formulation-specific testing. The platform supports research and comparison; it does not establish that every formulation improves or that CO₂ always outperforms another method.
What is included in the base configuration?
The supplied description identifies a 2.5 L processing vessel, controlled CO₂ antisolvent pulse transfer, a static-mixer transfer path, and a separate 10 L collection vessel. Confirm the approved equipment specification and proposal for final inclusions.
Are all feed options standard?
Co-solvent is an option we scope for your study. External preparation and multi-feed arrangements are proposed research configurations. Ask the team to confirm availability, engineering scope, and what is included for your project.
What should our team prepare before a technical call?
Bring your active and carrier and the result you need, sample constraints, expected project frequency, site and utility questions, and the people who will operate or approve the equipment.
Application fit · Study scope · Equipment
What does your formulation need to do?
Share a nonconfidential description of your active and carrier and the result you need. Tell us whether you need a feasibility study or in-house equipment. Use the form to request a 15-minute technical discussion. Our team will contact you to coordinate a time.
Prefer to call? 651-600-0036.